I have the same problem as well.  If I upgrade QB Desktop Enterprise 2022 to R5, it crashes at the splash screen.  I have 2 QB Servers that host the company files with QB installed and 4 Remote Desktop Servers with QB installed where my users access the files.  I only have this problem on a single server; all servers have Windows Server 2012 R2 installed and are updated and current.  I've traced the problem to a bad certificate that is only installed on the crashing server.  I'm in the process of attempting to remove that certificate permanently.  I'll post my results if it works.