I have the same problem as well. If I upgrade QB Desktop Enterprise 2022 to R5, it crashes at the splash screen. I have 2 QB Servers that host the company files with QB installed and 4 Remote Desktop Servers with QB installed where my users access the files. I only have this problem on a single server; all servers have Windows Server 2012 R2 installed and are updated and current. I've traced the problem to a bad certificate that is only installed on the crashing server. I'm in the process of attempting to remove that certificate permanently. I'll post my results if it works.
