I want to thank everyone who responded to my post.  I was able to get it resolved.

It turns out when I clicked on KY  for the tax state - for one of our new remote EEs - QBs did not have any info on who to pay the KY withholding or UI to.  I did not get an error at that time.

I have not even run a payroll yet with that KY EE in it - but since I selected KY on their EE tax state - QBs did not like that.

I just wanted to thank everyone who left a suggestion.