I want to thank everyone who responded to my post. I was able to get it resolved.
It turns out when I clicked on KY for the tax state - for one of our new remote EEs - QBs did not have any info on who to pay the KY withholding or UI to. I did not get an error at that time.
I have not even run a payroll yet with that KY EE in it - but since I selected KY on their EE tax state - QBs did not like that.
I just wanted to thank everyone who left a suggestion.
