Oddly this just started in the current version I'm using when I changed my monitors in my home office. I had this issue previously on a different computer with a different company, but it was fixed by changing to a newer version of QB Desktop. Now the problem has started again and changing my main display to where ever I have QB Desktop is allowing me to change column widths. The problem I see is that going forward, when I am in a different office with different monitors, I'll have to figure out which monitor is my main display.

And the other fix suggested below made QB even slower to load than it already was. Time to change it back.