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Buy nowHi there, Brian 413. Thanks for joining the thread and providing detailed information about your concern.
A data integrity issue could be the reason why the subtotal changes when saving or printing the invoice. In this case, let's run the Verify Rebuild Data tool that helps identify and repairs data issues within your company file. Here's what you'll need to do:
For more details about the Verify/Rebuild process, check this article: Verify and Rebuild Data in QuickBooks Desktop.
Once done, check to see if everything is working now.
You'll also want to visit this link for more troubleshooting steps: Fix data damage on your QuickBooks Desktop company file.
Please let me know how things go on your end. I want to ensure this gets resolve for you. Take care.