I’ll help you resolved this, @tkfitzsimmons.

There are several causes of this error you’ve encountered. It can be a system file corruption, or the Microsoft .NET Framework installation is corrupt.

QuickBooks Desktop uses Microsoft programs to run web-based apps. Once the .NET Framework has an issue, QuickBooks may not work properly.

In more severe circumstances, a clean install or repair install can help you. You can download the QuickBooks Tool Hub, then use the QuickBooks Install Diagnostic Tool to get this resolved. Here’s how:

1. Close QuickBooks.
2. Download the most recent version (1.4.0.0) of the QuickBooks Tool Hub.
3. Save the file.
4. Open the file you downloaded (QuickBooksToolHub.exe).
5. Follow the on-screen steps to install and agree to the terms and conditions.
6. Double-click the icon on your Windows desktop to open the tool hub.
7. In the tool hub, select Installation Issues.
8. Select QuickBooks Install Diagnostic Tool. It can take up to 20 minutes.
9. Restart your computer when finished.

You can refer to this guide on how to fix QBDT install errors. Just proceed to the remaining instructions (3-5) if the issue remains.

In addition, here’s a reference to manually fix Microsoft .NET Framework errors. Follow the steps for your operating system.

Don't hesitate to visit me here with an update on your application. I’m always here to help. Take care!