Unfortunately you are not reading understanding what this user is saying, I am experiencing the exact same issue and it has NOTHING to do with the database file - i experienced this after installing QB Enterprise 21 Accountants Edition - suddenly none of my users can even launch the application anymore without us calling our IT department and having the IT administrator allow them to launch the app, then when they open the database, it will prompt them 3 more times for admin password to the Windows OS.  This is not right, something is wrong here folks.  Bookkeepers are not IT system administrators, we only give our bookkeepers admin access to our QB files, not our entire IT infrastructure.  Attached are screen shots of the various messages - disabling UAC still prompts you to press continue 3 times.