Hello there, just4julia. Yes, it is possible in QuickBooks Desktop.

We only need to turn on something in the preference. Let me guide you how:

1. Let's go to Edit from the main menu.
2. Click Preferences and select Sales Tax.
3. Put a check mark inside the Identify taxable amounts as "T" for "Taxable" when printing.
4. Then, OK.

Within the invoice or when we print invoices, we'll be able to determine if the item is taxable or not.
 

Visit us again if you need anything else. I'm willing to help you more. Stay safe and healthy!