Yes - as with others, fully capable of changing Display Settings in Win10 environment with multiple HD screens.  Doesn't matter.  While some of the actual QB functionality is too big - it is serviceable.  What is maddening and useless is that ALL pop-up windows e.g., Help is so small as to be unreadable and there is no onscreen adjustment allowing the user to adjust e.g., as can do in any normal browser.  It is your API for those pop-up utilities. 

And this was an absolute clean install as had to migrate from Premiere to Professional to pay the hostage fees of maintaining Payroll function for company less than 5 people - in an of itself, a ridiculous three year tax.  Since same small font problem was happening in Premiere, was hoping it would be functional in Pro.