Are the remote users connecting wirelessly?  We use Enterprise as well (going on 10 years) and found out a couple of years in that you CANNOT connect wirelessly without data corruptions errors being a huge problem.  I was working in the office on a wireless connection through our internal network and would periodically get booted out.... maybe a hiccup or burp in the connection?  Regardless of the cause, any time that happened, I would lose part of a transaction and my trial balance / balance sheet / income statement would be thrown out of balance (debits did NOT equal credits).  After some intense discussions, we determined that all connections have to be hard wired - that is - plugged into a stable internet connection.  Hope this helps.