I acknowledge the steps you've taken to troubleshoot the issue according to my colleague's suggestions, gerdgoebel. Allow me to join this conversation and provide additional support to help you eliminate the presence of pop-up ads.

After disabling the Turn off popup messages for products and services, no advertisements should appear on your display. If you're still receiving the same issue, we can proceed with the selection to use the tools in the hub. Specific to your concern, we can follow these steps:

• Company File Issues: Run the Quick Fix my file or the QuickBooks File Doctor to fix common data issues. If you need more help, select File Dr Help.
  

You can visit this article for additional info about Tool Hub usage: Fix common problems and errors with the QuickBooks Desktop Tool Hub. 

I'm still here if you need any help with adjusting specific display settings in QBDT, gerdgoebel.  Just let me know in the comments and I'll do my best to assist you. I'm here to support you in ensuring you can work on your preferred configuration.