I've narrowed down the problem to FedEx Ship Manager v3709. QB 2019, 2021 and 2023 (trial) run just fine until FedEx Ship Manager v3709 is installed. Once FSM is loaded all versions of QB begin freezing. Aside from QB all other software continues to operate normally and without issue.

The drive image from the old 3rd gen Intel PC with FSM v35xx runs just fine when restored to a new PC. I'm going to upgrade FSM today, when I find some time, and see if it begins freezing as well.