Anyone ever see this error message before?  

"App Connection"

Quickbooks isn't able to sync data with your app(s).  It could be possible due to following reasons:

Your internet connection might be down

You might be signed out of your intuit account

You might be facing a system error

To fix the problem, select Web Apps and reconnect the app.

This error pops up for my client every day at 12:30 PM.  There are no apps under File > App Connections...in fact - she gets an error message that she is not authorized to view anything under File > App Connections.  QB web connector is not running.  They use a product called shipgear to interface with quickbooks and have their shipping program (fedex) be able to look up order details inside Quickbooks to post to the shipment.  I tend to think it is this interface causing the issue....that said - 2 others in the office use the same setup and are not getting this error message every day.  I have uninstalled / reinstalled Quickbooks and checked for any updates.  I have also made sure antivirus is not scanning the computer at this time and no other devices are plugged into the computer except monitor, mouse, keyboard.