We installed QB2022 in May, 2022 on two computers in our office. Both of them have Windows 2010 OS, but both are entirely different machines. Both of the pc's have experienced the unexpected QB closing that happens at mostly random times. Quite unexpectedly, we have found that if Outlook is opened  before QB, we get the unexpected disappearing / crashing problem. If we open Outlook after QB, we do not have the unexpected disappearing / crashing. Don't ask me to explain it, I can't. I just know that is how we solved the issue for our office.