Welcome to the club, my users have been experiencing this for the past month and a half. Intuit support clearly could not care less. Scheduled a call with support 12 days ago and after (wish I was exaggerating) 5+ hours on the phone, they still could not figure out why loading QB company files caused crashing of Chrome, Excel, and Outlook. Over an hour of this was spent arguing with the tech that it's not a Microsoft problem, but a QB problem (it only happens when switching company files, and occurs on all of our workstations). Finally was able to get them to open an investigation and haven't heard back since...

I was able to narrow down that the issue lies in the R4 or R5 update of QBDT22. When I got all of my accountants set up with new computers, QB was working great because we installed with an older R3 version's install file. Then they started seeing messages to update, and it wasn't until they applied the R4 or R5 version update that the problem returned. A great workaround would be to just keep R3 installed and not update until Inuit figures out the issue, but QB only lets you skip an update 3 (maybe 5?) times before it won't open and you are forced to update.

Seriously disappointed in how Intuit is dealing with this problem that so many others in this thread seem to also be struggling with. My users are even more disappointed as they've been dealing with this firsthand for over 6 weeks.