@Denyel 

Are you running Win 10 21H2.19044 or older version?

Can you open the sample file?

A few minutes ago, my shortcut on the dashboard to run QBD 2021 Premier was broken and the error was silly because the QBW32PremierGenereic.exe file was missing. We did the same thing by clicking the same shortcut a few hours ago and QB Desktop 2021 run normally. I looked for the filename in the QB Desktop 2021 folder and ran it manually. On the screen I noticed a message box saying that Windows is updating QuickBooks with a progress bar. A few minutes later, I can open any file in my QBD 2021. I'm not sure what really happened.