There are a few steps we can take to troubleshoot the error causing hindrance when opening QuickBooks Desktop, tpi4tom.

First, make sure you're using a supported version of QuickBooks for compatibility. If not, upgrading your QuickBooks is a good start to fix unexpected errors and odd behavior. You can check this link for more additional details: QuickBooks Desktop service discontinuation policy.

Then, it's important to enable the .NET Framework 3.5 to ensure a smooth experience with QuickBooks Desktop on Windows 10. In your case, it may not have been enabled by default.  No worries, here's how you can do it:

1. Press the Windows + R on your keyboard to open the Run window.
2. Type Control Panel and then click OK.
3. In the Control Panel, select Uninstall a Program and then click on Turn Windows features on or off.
4. Make sure that both the .NET Framework 3.5 and .NET Framework 4.5 are enabled (checked).

If the same thing happens, you can install the most recent version of the QuickBooks Tool Hub and run QuickBooks Fix my Program to fix issues when you can't open QuickBooks.

1. Download the most recent version of the QuickBooks Tool Hub. Once the download is complete, open the downloaded file (QuickBooksToolHub.exe).
2. In the QuickBooks Tools Hub, locate and select the Program Problems option.
3. From the available options, choose Quick Fix my Program.
4. After the tool completes the fix, launch QuickBooks Desktop.

When you upgrade to Windows 11, please note that only QuickBooks Desktop 2022 versions (Pro Plus, Premier Plus, Pro, and Enterprise) with R3 or later are officially certified as fully compatible with the 64-bit version of Windows 11. Visit this article: QuickBooks Desktop and Microsoft Windows 11. It will serve as a guide about QuickBooks Desktop system requirements and Microsoft Windows 11 compatibility. 
 

If you have more concerns about opening QuickBooks and need help resolving errors, please go back here anytime. I'll help you right away. Take care and have a good one.