Same issue for us. With ours it begin with an updated to Enterprise 22. So far I've been working with customer support for 5 weeks, over 15 hours on the phone.  They keep trying to say it's almost fixed.  At this point the assurances are laughable.  

I do feel like I'm inching closer to a solution.  The turning off the cloud thing didn't work for us.  Neither did updating 87 times with tech support on the phone or any of the other fixes the support agents tried.  Eventually they had to install new PSID number, which reset our account.  After that we could transmit again but the account was locked, so that was another call to support and a form that had to be faxed in.  Once the password issue was resolved, the send payroll data function works but direct deposit is no longer activated.  For some reason the software thinks it is active so the add direct deposit options don't appear in my menu, but the back end says QB (so unhelpfully) deactivated direct deposit as part of their fix.  I'm now in the phase of waiting for the back end to reactivate our bank account.  I was told it would take 2 days to complete, that was 10 days and 7 calls ago.  Who knows if it will ever be done. 

Every time I have to call QB support, I feel like they reach a new low in the support they provide.  My employees and the company CEO are getting pretty annoyed with the broken direct deposit, so we will probably end up switching to another payroll provider if the issue isn't resolved this week.