I'm here to share some insights about setting up employee information in QuickBooks Online (QBO) Payroll, @sharon108.

Yes, you're correct. The employee's home address in their profile is where QBO mails out their W2's. For the time being, you're unable to use a PO Box as an address when setting up an employee's info in QBO. With this, I'd recommend consulting the IRS regarding this matter. This way, you can keep your employee's account is compliant with the agency's policy.

Also, to further guide you in managing employees and payroll transactions in QBO Payroll, I'd recommend checking out this article: Getting employee records accurate for payroll.

Please don't hesitate to let me know if you have other payroll concerns and questions about managing employees in QBO Payroll. Drop a comment below, and I'll gladly help. Take care, and I wish  you continued success, @sharon108.