Thank you for joining the thread, @cmrapp.

Yes, QuickBooks Online (QBO) supports multi-state employment. However, consulting with an accountant or a tax professional is highly recommended to help set up the employees correctly so QuickBooks will calculate and deduct taxes accordingly.

Also, you can contact our QBO Support Team with regards to your payroll questions. From the Help menu, select Contact us to connect to a payroll representative.

This article is another great resource to know more about multi-state employment payroll situations in QBO: About multistate employment payroll situations.

Drop a post if you have any other concerns and clarifications, I'm always here to help however I can. Wishing you continued success!