This isn't a Profile issue.  Rather, it is CRA deciding that this particular client requires a Pre-Assessment Review.  CRA routinely does both Pre and Post Assessment Reviews to insure that our tax system is working properly.  Sadly, the audit message on e-filing doesn't always show that a Pre-Assessment Review was triggered. I've experienced this many times over the years, both with Profile and also with the current software that I'm using this year (not Profile), where the software reports that the return was filed and processed successfully, but then I log into CRA and see the message that it is being Assessed. I've experienced these delays to be resolved from within days on the short end, but up to a month on the long end.  Usually they are resolved without sending the client any letters for documentation - they simply need an agent to review the file and usually it passes the review and the NOA is issued.  
Hope this helps.