This has been an ongoing issues for a long time.  We have been on Quickbooks for over 20 years.  Each time I 'upgrade', this same issue happens.  We have Advanced Inventory as well, so some of the fixes pf closing and opening a PO are not an option.  At one time we tried to make sure there are no blank lines on a PO. We would manually review ea PO and non-inventory item, blank lines or notes must be deleted, as item receipts view ea line as something to be added to inventory.  Blank lines at the bottom of the iPO were an issue for a while, the simple act of hitting ENTER would add "invisible product" that never gets received.  These blank lines would not show in the item receipt but create havoc in the 'path'.  We have just updated to the 22.0 version and are in a hosted environment.  Bills, inventory receipts, POs worked fine in 19.0.  This new version is really creating issues for us with regard to the PO not showing to be paid in Bills.     

We have verified and rebuilt and gone through all the steps listed on every post. We couldn't possible re enter all of the POs as our small business has probably outgrown QB, we use it to its fullest capacity.