@GG64  I've been e-filing and e-paying in QB desktop for multiple clients for over a decade with very few problems. 

I wonder, do you have a federal e-FILING pin and is it correctly entered when you try to e-file your federal forms?  This is different from your EFTPS payment pin - completely different system.  The process can be a little tricky.  For e-filing, you have to apply for the pin, wait for it to arrive in the mail, confirm its receipt with the IRS, wait for them to activate it, and then enter it when you efile.  There's no way to enter it and save it ahead of time in QB, and no way to hurry the process.  If you want to efile for next quarter, you need to start now. 

For EFTPS, you will need to go onto the EFTPS website, change your internet password to a 12 digit password, wait at least 24 hours, then make a payment and update the QB password to match the changed password.  That process can be made more complicated if you have changed your bank account or your EFTPS pin.  

If that doesn't help, you might try reaching out to a ProAdvisor for assistance.  It would be worth the fee!