Could someone answer this with definitive yes or no as it is not clear through out this. As @Bookkeeper8 stated it seems like that one drive would not work if you are using QB in multi user mode and expect to have more than one QB instance running and accessing the Company file however if you are only going to have one instance of QB running at a time you can use one drive to store your company file. 

All of the discussion about the DB and not updated in a timely fashion makes sense when multiple instances of QB is connecting to the company file via one drive but it does not make sense as to why one drive wouldnt work when you only have one instance of QB accessing that file at a time.