I have come to agree with Fiat Lux. I recently moved to TopBox for cloud storage which automatically syncs from my local hard-drive to the TopBox cloud. I have run, literally, dozens of tests. Quickbooks Desktop cannot open the Company File, not matter how I try to do it. It always fails. I must first copy the file from the cloud to a local drive that is not being linked to the cloud. Do my Quickbooks work. And then, copy the file back to the cloud. In my case, I only copy the QBW file. That file is all that is needed for Quickbooks to open the Company and generate all of the other needed Quickbooks files.